Title

The effects of adolescent ADHD medication on adult addiction susceptibility

Proposal Type

Event

Keywords

ADHD, abuse, addiction, amphetamine, adolescence, dopamine, neuroplasticity, behavioral sensitization, sexual dimorphism, methamphetamine

Subject Area

Biology

Description/Abstract

During adolescence, the dopaminergic areas of the brain undergo continued development. These areas are often considered to be responsible for incentive-motivated and risk-taking behaviors [1]. Amphetamine (AMPH) increases dopamine (DA) in the synapse both by blocking the monoamine transporters and by releasing DA from synaptic stores and the nerve terminal [2]. Prescription AMPH, such as Adderall®, is one of the most common prescription drugs abused by students and it is possible that adolescent abuse of AMPH could lead to increased substance abuse in adulthood [3]. Because of the similarities between AMPH and Methamphetamine (METH), early AMPH abuse could create neurological changes during adolescent development that prime for METH abuse in adulthood [4]. Expanding on the findings of previous studies in this lab, the current study hypothesized that mice exposed to small, clinically relevant doses of AMPH during adolescence will show behavioral cross- sensitization to a sub-acute dose of METH during adulthood, and that males will demonstrate a higher response when compared to females. Such a response would indicate that AMPH abuse during this adolescent developmental window resulted in long lasting, sexually dimorphic neurological change.

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The effects of adolescent ADHD medication on adult addiction susceptibility

During adolescence, the dopaminergic areas of the brain undergo continued development. These areas are often considered to be responsible for incentive-motivated and risk-taking behaviors [1]. Amphetamine (AMPH) increases dopamine (DA) in the synapse both by blocking the monoamine transporters and by releasing DA from synaptic stores and the nerve terminal [2]. Prescription AMPH, such as Adderall®, is one of the most common prescription drugs abused by students and it is possible that adolescent abuse of AMPH could lead to increased substance abuse in adulthood [3]. Because of the similarities between AMPH and Methamphetamine (METH), early AMPH abuse could create neurological changes during adolescent development that prime for METH abuse in adulthood [4]. Expanding on the findings of previous studies in this lab, the current study hypothesized that mice exposed to small, clinically relevant doses of AMPH during adolescence will show behavioral cross- sensitization to a sub-acute dose of METH during adulthood, and that males will demonstrate a higher response when compared to females. Such a response would indicate that AMPH abuse during this adolescent developmental window resulted in long lasting, sexually dimorphic neurological change.