Title

Adolescent Exposure to Methamphetamine Leads to Sensitization of Methamphetamine in Adult Mice [Poster]

Faculty Mentor(s)

Ryan Shanks and Steven Lloyd

Proposal Type

Poster

Location

Library Technology Center 3rd Floor Open Area

Start Date

29-3-2012 4:30 PM

End Date

29-3-2012 6:30 PM

Description/Abstract

Methamphetamine (METH) is a psychostimulant drug that causes severe physical and mental effect on its users. Adolescent METH users may be prone to addiction because this is a critical window of development in the brain. METH is a dopamine (DA) agonist which causes behavioral activation and acts as a motivator for exploration and excitability. Changes in DA levels and the inhibition of DA reuptake result in increased locomotor activity, also called sensitization. Sensitization is a phenomenon that occurs when pretreatment with one stimulant leads to greater sensitivity when exposed again in the future. Given that adolescence is a period of neural development, we proposed that adolescent mice exposed to METH will show an increase in sensitization when exposed to a sub-acute challenge dose in adulthood. [POSTER]

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Mar 29th, 4:30 PM Mar 29th, 6:30 PM

Adolescent Exposure to Methamphetamine Leads to Sensitization of Methamphetamine in Adult Mice [Poster]

Library Technology Center 3rd Floor Open Area

Methamphetamine (METH) is a psychostimulant drug that causes severe physical and mental effect on its users. Adolescent METH users may be prone to addiction because this is a critical window of development in the brain. METH is a dopamine (DA) agonist which causes behavioral activation and acts as a motivator for exploration and excitability. Changes in DA levels and the inhibition of DA reuptake result in increased locomotor activity, also called sensitization. Sensitization is a phenomenon that occurs when pretreatment with one stimulant leads to greater sensitivity when exposed again in the future. Given that adolescence is a period of neural development, we proposed that adolescent mice exposed to METH will show an increase in sensitization when exposed to a sub-acute challenge dose in adulthood. [POSTER]