Title

The effect of natural products on the growth of docetaxel resistant androgen independent prostate cancer cells expressing cancer stem cell markers.

Presenter Information

Ramneet KaurFollow

Academic Title

Lecturer of Biology

College

Science and Mathematics

Department

Biology

Primary Campus

Gainesville

Title of Award Granted

Presidential Incentive Award

Name of Institution that Granted the Award

University of North Georgia

Keywords

Prostate cancer, Natural products, Cancer stem cells, Molecular Docking

Abstract

Prostate cancer is the most common malignancy afflicting the lives of men worldwide. Prostate cancer has two stages, androgen dependent and androgen independent. In the androgen dependent stage, the prostate cancer can be treated by hormone depletion therapy. In androgen independent stage the hormone depletion therapy does not work. The only available treatment for androgen independent prostate cancer is FDA approved chemotherapy drug docetaxel. Patients initially respond to docetaxel and then they become resistant to it. The cells that are resistant to docetaxel express cancer stem cell markers and represent the population of cancer stem cells. The goal of this project is to analyze some chemicals found in natural products as treatment for docetaxel resistant prostate cancer cells. Analysis is being done by molecular docking using tools like Chimera and Autodock Vina. MIC1 and BCL2 are the proteins which get overexpressed in response to docetaxel resistance and are used as receptors in the study. This project involves using the natural products which are well tolerated by human body for solving the problem of drug resistance in prostate cancer cells and developing an effective treatment for this deadly disease.

Biography

Dr. Ramneet Kaur is a lecturer of Biology on the Gainesville campus. Since 2018 she has been actively involved in cancer research using natural products and has an active research program running under her guidance. She has received many internal grants at UNG to pursue her research work.

Proposal Type

Poster

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Additional Presenter Information

Lecturer of Biology, College of Science and Mathematics, Biology, Gainesville Campus.

Subject Area

Biology

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The effect of natural products on the growth of docetaxel resistant androgen independent prostate cancer cells expressing cancer stem cell markers.

Prostate cancer is the most common malignancy afflicting the lives of men worldwide. Prostate cancer has two stages, androgen dependent and androgen independent. In the androgen dependent stage, the prostate cancer can be treated by hormone depletion therapy. In androgen independent stage the hormone depletion therapy does not work. The only available treatment for androgen independent prostate cancer is FDA approved chemotherapy drug docetaxel. Patients initially respond to docetaxel and then they become resistant to it. The cells that are resistant to docetaxel express cancer stem cell markers and represent the population of cancer stem cells. The goal of this project is to analyze some chemicals found in natural products as treatment for docetaxel resistant prostate cancer cells. Analysis is being done by molecular docking using tools like Chimera and Autodock Vina. MIC1 and BCL2 are the proteins which get overexpressed in response to docetaxel resistance and are used as receptors in the study. This project involves using the natural products which are well tolerated by human body for solving the problem of drug resistance in prostate cancer cells and developing an effective treatment for this deadly disease.